Epididymal Sperm Granuloma Induced by Chronic Administration of 2-Methylimidazole in B6C3F1 Mice

P-2: Evaluation of Epididymal Sperm Quality, DNA Damage and Sperm Maturation Abnormality in Streptozotocin- induced Diabetic Mice

Background: Diabetes mellitus, a condition of chronic hyperglycemia, represents one of the greatest concerns to modern global health. Diabetes is a serious metabolic disorders with numerous complications. It is well known that, elevation of blood glucose levels leads to structural and functional changes in various target tissues and organs. The objective of the present study was to verify if th...

The effects of long-term administration of tramadol on epididymal sperm quality and testicular tissue in mice

Objective- The objective of the present work was to investigate the effects of tramadol administration on sperm quality and testicular tissue in mice. Design- Experimental study Animal- Sixty-three mature male mice Procedures- Mice were randomly divided into three experimental groups (n=21) and the following treatments were intraperitoneally administered, 3 times a week, for 6 weeks: Control...

Prevention of di (2-ethylhexyl) Phthalate-induced Testicular Disturbance in Mice by Co-administration of L-carnitine

P-33: Epididymal Sperm Analysis afterTime Dependant Administration of Methylphenidate in Adult Male Rats

Background: Methylphenidate is one of the most common medications used for treatment of attention-deficit/hyperactivity disorder. It may be used for maintaining alertness and improving of attention which may lead to increase of the risk of substance abuse in some cases. The occurrence of alteration in male reproductive system such as hormonal secretion changes and alteration of testicular sperm...

Busulfan induces oxidative stress- and Bcl-2 family gene-related apoptosis in epididymal sperm and testis of adult male mice

Introduction: Busulfan as a chemotherapeutic agent causes testicular germinal epithelium depletion and cytotoxicity in germ cells. The aim of this study was to assess antioxidant status, reactive oxygen species (ROS) generation and apoptosis-related genetic markers of adult male mouse sperm following busulfan treatment. Materials and Methods: Forty adult NMRI mice (30 ± 5 g) were divided...